课件大小： 573KB
课件格式： pdf
添加时间： 2008-8-20 12:57:00
来源： HEPATOLOGY, Vol. 47, No. 6, 2008
作者： Eve A. Roberts and Michael L. Schilsky
积分限制:2
::课件简介:
:Copper is an essential metal that is an important cofactor for many proteins. The average diet provides substantial amounts of copper, typically 2-5 mg/day; the recommended intake is 0.9 mg/day. Most dietary copper ends up being excreted. Copper is absorbed by enterocytes mainly in the duodenum and proximal small intestine and transported in the portal circulation in association with albumin and the amino acid histidine to the liver, where it is avidly removed from the circulation. The liver utilizes some copper for metabolic needs, synthesizes and secretes the copper-containing protein ceruloplasmin, and excretes excess copper into bile. Processes that impair biliary copper excretion can lead to increases in hepatic copper content.
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